TABLE 1

GI50s of CXL146 and mitoxantrone toward parental and MDR cancer cell lines

Selectivity is the ratio of GI50 of the parental cell line to that of the MDR cell line.Embedded Image CXL146Mitoxantrone
Cell lineGI50 (µM)SelectivityGI50 (µM)Selectivity
HL600.48 ± 0.0710.0040 ± 0.00031
HL60/MX20.17 ± 0.032.80.18 ± 0.010.02
HL60/DOX0.30 ± 0.071.60.007 ± 0.0010.57
K5620.75 ± 0.0910.31 ± 0.051
K562/DOX0.49 ± 0.111.50.89 ± 0.040.35
K562/HHT3000.51 ± 0.031.53.8 ± 0.20.08