TABLE 1

miRNAs potentially targeting ADH and ALDH genes

Gene SymbolTranscriptmiRNA SymbolTargeting PositionFree Energy (kcal/mol)aCorrelation (r)b
ALDH8A1NM_170771hsa-miR-1301-3p1911–1932−30.6−0.480
ADH6NM_000672hsa-miR-1301-3p1274–1301−28.3−0.469
ALDH5A1NM_001080hsa-miR-1301-3p1824–1845−26.8−0.459
ALDH3A2NM_000382hsa-miR-1301-3p2681–2702−26.8−0.353
ALDH5A1NM_001080hsa-miR-149-3p2074–2090−33.0−0.365
ALDH4A1NM_003748hsa-miR-149-3p2619–2639−28.6−0.252
ALDH5A1NM_001080hsa-miR-149-5p2512–2533−24.4−0.365
ADH4NM_000670hsa-miR-185-5p1572–1593−22.2−0.270
ALDH3A2NM_000382hsa-miR-186-3p2501–2522−20.0−0.256
ALDH5A1NM_001080hsa-miR-18a-5p2015–2035−22.0−0.348
ALDH5A1NM_001080hsa-miR-330-5p1835–1856−26.3−0.402
ALDH5A1NM_001080hsa-miR-330-5p2008–2029−32.5−0.402
ALDH4A1NM_003748hsa-miR-330-5p2636–2657−22.4−0.339
ALDH1B1NM_000692hsa-miR-532-3p2943–2964−23.6−0.296
ALDH4A1NM_003748hsa-miR-766-3p2393–2414−35.2−0.285
ALDH4A1NM_003748hsa-miR-766-3p3059–3080−30.0−0.285
ALDH5A1NM_001080hsa-miR-93-3p4543–4564−22.7−0.262
ALDH9A1NM_000696hsa-miR-93-5p2314–2335−25.2−0.454
ALDH1A3NM_000693hsa-miR-93-5p2361–2382−25.5−0.258
  • a Calculated by the RNAhybrid program.

  • b All P < 0.05. The correlations between the expression of potential candidate miRNAs and the RNA levels of their cognate targeting genes based on the liver data set from TCGA data base were calculated by Pearson correlation analysis.