TABLE 1

Kinetic parameters for p-aminobenzoic acid acetylation by NAT1 with constant AcCoA (1 mM)

ConditionVmax (nmol/min per Density Unit)Km (µM)Ki (mM)
Nonacetylated72 ± 2212 ± 102.01 ± 0.15
Acetylated47 ± 1a211 ± 62.92 ± 0.18a
  • aP < 0.01 compared with nonacetylated enzyme by Student’s t test with 19 degrees of freedom.