KET and HNK potency on NMDA receptor isoforms
Data are means and 95% confidence intervals.
| N1/N2A | N1/N2B | ||||
|---|---|---|---|---|---|
| IC50 (µM) | Number of cells | IC50 (µM) | Number of cells | ||
| HNK | pH 6.8 | 46 (95% CI 31–68) | 3 | 39 (95% CI 32–47) | 3 |
| pH 7.2 | 46 (95% CI 38–56) | 5 | 69 (95% CI 26–184) | 6 | |
| KET | pH 6.8 | 0.8 (95% CI 0.6–0.9) | 3 | ||
| pH 7.2 | 0.5 (95% CI 0.3–0.7) | 3 | |||
| pH 7.6 | 2.2 (95% CI 1.6–2.9) | 3 | |||