TABLE 3

State-dependent actions of KET and HNK on NMDA receptor responses

Data are means Embedded Image S.D.

Ipeak (pA)Tau D (s)Iss/Ipeak
Glutamate−1731 Embedded Image 3581.7 Embedded Image 0.40.53 Embedded Image 0.02
Coapply KET (n = 4)−1749 Embedded Image 7360.8 Embedded Image 0.20.26 Embedded Image0.07 (P = 0.02)*
Glutamate−1347 Embedded Image 7011.6 Embedded Image 0.30.54 Embedded Image 0.07
Coapply HNK (n = 4)−1057 Embedded Image 622 (P = 0.01)*0.6 Embedded Image 0.1 (P = 0.01)*0.20 Embedded Image 0.03 (P = 0.001)*
Glutamate−805 Embedded Image 4381.5 Embedded Image 0.20.54 Embedded Image 0.05
Preapply KET (n = 3)−441 Embedded Image 242 (P = 0.02)*1.1 Embedded Image 1.50.18 Embedded Image 0.03 (P = 0.0002)*
Glutamate−2061 Embedded Image 17601.4 Embedded Image 0.40.44 Embedded Image 0.10
Preapply HNK (n = 5)−1471 Embedded Image 1560 (P = 0.01)*1.3Embedded Image 0.40.36 Embedded Image 0.14

  • ↵* Steady-state current (Iss), Peak current (Ipeak). Data are means ± S.D., *P values determined by paired t test.