Surface accessibility of Tyr and Cys residues of CYP2B6

Surface accessibility (Ratio %) for the CYP2B6 closed structure was calculated from “Get Area (” using the Protein Data Bank structure 3IBD. The open structure of CYP2B4 (1PO5) was used to model the CYP2B6 open three-dimensional structure by using Modeler (, and then surface accessibility was calculated in the same manner. Residues shaded in gray were selected for the initial mutational analyses.

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