TABLE 1

Surface accessibility of Tyr and Cys residues of CYP2B6

Surface accessibility (Ratio %) for the CYP2B6 closed structure was calculated from “Get Area (http://curie.utmb.edu/getarea.html)” using the Protein Data Bank structure 3IBD. The open structure of CYP2B4 (1PO5) was used to model the CYP2B6 open three-dimensional structure by using Modeler (http://salilab.org/modeller/), and then surface accessibility was calculated in the same manner. Residues shaded in gray were selected for the initial mutational analyses.

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