TABLE 2

Published data on RTI compounds

Compound	αβ	α7	ED₅₀	ED₅₀	ED₅₀	ED₅₀	AD₅₀
	Epibatidine	MLA	mg/kg	mg/kg	mg/kg	mg/kg	µg/kg	µg/kg
	Ki, nM	Ki, nM	tail flick	hot plate	hypothermia	activity	tail flick	hot plate
(+) epibatidine	0.026 ± 0.002		.0061	.0004	.0004	.001
(−) epibatidine	0.018 ± 0.001		.0066
Nicotine	1.5 ± 0.3		1.3		0.65	1.0	0.5
RTI-36^a^a	0.037 ± 0.001	>1000	0.08	0.05	0.15	0.23	0.07	35% @20
RTI-76^b^b	0.009 ± 0.001	1100 ± 157	0% @ 2	0%@ 2	3.3	2.0	20	560
RTI-102^c^c	0.009 ± 0.001		5% @10	10% @10		0.22	0.003	0.12

MLA, methyllycaconitine; AD₅₀, anesthetic dose for 50 % effect.