TABLE 1

HET mice exhibit significantly shorter times to isoEEG

WT and HET mice maintained with 1.5% HAL anesthesia were instrumented to continuously record EEG and ECG as described in the Materials and Methods. Data across genotype and treatment condition were analyzed using paired t test (OriginLab 9.0). Each genotype and treatment group had n = 3–4 mice.

Genotype	CAF	DAN	isoEEG	ECG arrest	EEG vs. ECG arrest
			Mean ± S.D., min	Mean ± S.D., min	P value
WT	−	−	>60.0	>60.0	N/A
WT	+	−	>60.0	>60.0	N/A
HET	−	−	12.3 ± 1.9	24.2 ± 5.2	0.018
	+	−	8.9 ± 0.8	17.2 ± 4.8	0.036
	+	+	25.8 ± 8.8	32.5 ± 11.7	0.041
	−	+	29.5 ± 9.7	38.5 ± 5.7	0.042

N/A, not applicable.