TABLE 1

Selectivity of peptidase inhibitors

InhibitorPeptidase SourceNEPNEP1NEP2APNACEReference
ThiorphanStriatal membranes4.7 nM150 nMRoques et al., 1980
Not stated4 nM>100 nMInguimbert et al., 2002
Expressed human6.9 nM22 µMWhyteside and Turner, 2008
Expressed rat4 nM120–250 nMRose et al., 2002
Porcine basilar artery1.4 nM295 nMMiyamoto et al., 2002
BestatinBrain membranes0.5–4µMGros et al., 1985
Porcine kidney4.1 µMRich et al., 1984
CaptoprilStriatal membranes10 µM7 nMRoques et al., 1980
Expressed human6.3 nMDalkas et al., 2010
Porcine basilar artery38 nMMiyamoto et al., 2002
Not stated>1000 nM2 nMInguimbert et al., 2002