Structure of recombinant chemokine analogs
| Compound | Structure | Inhibitory mechanism | References |
|---|---|---|---|
| CCL5 | SPYSSDTTP-CCL5 (10–68) | Cell surface steric blockade plus intracellular sequestration (trans-Golgi network) | Trkola et al., 1998; Escola et al., 2010 |
| PSC-RANTES | PSC-SSDTTP-CCL5 (10–68) | Enhanced intracellular sequestration (trans-Golgi network) | Hartley et al., 2004; Escola et al., 2010 |
| 5P14-RANTES | QGPPLMSLQV-CCL5 (10–68) | Intracellular sequestration (endosome recycling complex) | Gaertner et al., 2008; Bönsch et al., 2015 |
| 5P12-RANTES | QGPPLMATQS-CCL5 (10–68) | Cell surface steric blockade | Gaertner et al., 2008 |