TABLE 1

Summary of RGS2 protein-protein interactions

Listed are confirmed interactions for RGS2 and their functional consequences. This list is not comprehensive, and more interactions are likely to be found in the future.

Interacting proteinRegion of interactionFunctional consequenceReference(s)
Gα subunits
 GαqRGS domain; high affinityGAP activitye.g., Ingi et al., 1998; Nance et al., 2013
 Gαi1RGS domain; low affinityGAP activitye.g., Ingi et al., 1998
 GαsRGS domainModulate signaling; no GAP activityRoy et al., 2006
GPCRs
 AT1RN terminusInhibition of AT1R signalingMatsuzaki et al., 2011
 PAR1N terminus; third intracellular loop of PAR1; Gα dependentInhibition of PAR1 signalingGhil et al., 2014
 PAR4N terminus; third intracellular loop of PAR4; Gα dependentInhibition of PAR4 signalingKim and Ghil, 2020
 M1RN terminus; third intracellular loop of M1RInhibition of M1R signalingBernstein et al., 2004
α1ARN terminus; third intracellular loop of α1ARInhibition of α1AR signalingHague et al., 2005
β2ARN terminus; third intracellular loop of β2ARInhibition of β2AR signalingRoy et al., 2006
 MCH1RResidues 28–80Inhibition of MCH1R signalingMiyamoto-Matsubara et al., 2010
Other
 AC IIIN terminus; C1 region of AC IIIInhibits cAMP productionSinnarajah et al., 2001
 AC VN terminus; C1 region of AC VInhibits cAMP productionSinnarajah et al., 2001
 AC VIN terminus; C1 region of AC VInhibits cAMP productionSinnarajah et al., 2001
 eIF2BεResidues 79–115Inhibits protein synthesisWang et al., 2018
 PKGI-αRGS2 phosphorylationInhibits RGS2 degradation; promotes RGS2 membrane localizationTang et al., 2003; Osei-Owusu et al., 2007
 PKCPhosphorylation on Ser46Inhibits GAP activity in vitroCunningham et al., 2001
 TRPV6N terminusModulates channel activitySchoeber et al., 2006
 LRRK2UndeterminedControl of neuronal process length, protective against neuronal toxicityDusonchet et al., 2014
 Nek7UndeterminedMitotic spindle organizationde Souza et al., 2015
 FBXO44N terminusE3 ligase; promotes RGS2 protein degradationSjögren et al., 2015
 Teb4N terminusE3 ligase; promotes RGS2 protein degradationPark et al., 2015
  • α1AR, α1-adrenoreceptor; β2AR, β2-adrenoreceptor; eIF2Bε, Eukaryotic Initiation Factor 2Bε; FBXO44, F-box only protein 44; M1R, muscarinic M1 receptor; MCH1R, melanin-concentrating hormone receptor 1; PAR4, protease-activated receptor 4; PKGI-α, cGMP-dependent protein kinase I-α; TRPV6, Transient Receptor Potential Vanilloid subfamily member 6.