TABLE 2

UV-visible quantification of the AcCYP51 ligand-bound fractiona

LigandLigand, μMAcCYP51, μMAcCYP51 ligand, μMFraction of ligand-bound AcCYP51, %
n1n2n1n2
Clotrimazole20.05.00.810.6616.213.0
Isavuconazole20.05.00.470.389.47.6
31-Norlanosterol20.05.00.901.0018.020.0
  • a Experiments were performed in duplicates. Values for the replicates n1 and n2 are shown separately.