TABLE 1

Potential proteins that may be involved in S protein processing and ACE2 interaction

Protein Implicated in SARS-CoV-2 EntryBLASTp Results in Human Protein Data BaseSequence Identity (Filter: min ∼50%)Relevance (UniProKb Data Base)
Furin proteaseCadherin-related family member 455.6%Expressed in lung, uterine tube, testis (similar pattern to ACE2 prominent distribution) single-pass transmembrane protein.
Isoform 7 of tumor necrosis factor receptor superfamily member 2550%Interacts with receptor adapter protein TRADD and activates NF-κB, which are involved in inflammatory-induced apoptosis. May play a role in regulating lymphocyte homeostasis.

BLASTp, protein-protein basic local alignment research tool; NF-kB, nuclear factor kB; TRADD, tumor necrosis factor type 1-associated DEATH domain protein