Potential proteins that may be involved in S protein processing and ACE2 interaction
| Protein Implicated in SARS-CoV-2 Entry | BLASTp Results in Human Protein Data Base | Sequence Identity (Filter: min ∼50%) | Relevance (UniProKb Data Base) |
|---|---|---|---|
| Furin protease | Cadherin-related family member 4 | 55.6% | Expressed in lung, uterine tube, testis (similar pattern to ACE2 prominent distribution) single-pass transmembrane protein. |
| Isoform 7 of tumor necrosis factor receptor superfamily member 25 | 50% | Interacts with receptor adapter protein TRADD and activates NF-κB, which are involved in inflammatory-induced apoptosis. May play a role in regulating lymphocyte homeostasis. |
BLASTp, protein-protein basic local alignment research tool; NF-kB, nuclear factor kB; TRADD, tumor necrosis factor type 1-associated DEATH domain protein