IC50 values of abacavir, nevirapine, lexibulin, clofarabine, and cladribine in ENT1 and ENT2 cell lines
Best-fit values from eq. 2 were compared using the extra sum-of-squares F-test. IC50 values presented as mean and 95% C.I. with n = 3 and significance denoted by *P < 0.05 and ** P < 0.01.
| Nucleoside | ENT1 IC50 (μM) | ENT2 IC50 (μM) | P Value | Ratio ENT2:ENT1 |
|---|---|---|---|---|
| Abacavir** | 85.74 (95% CI: 34.22 to137.3) | 316.8 (95% CI: 113.3 to 520.2) | 0.0056 | 3.69 |
| Nevirapine* | 166.8 (95% CI: −32.88 to 366.6) | 17.78 (95% CI: 2.83 to 32.73) | 0.0113 | 0.11 |
| Lexibulin | 16.49 (95% CI: 0.776 to 32.20) | 21.32 (95% CI: −2.24 to 44.89) | 0.722 | 1.29 |
| Clofarabine | 31.48 (95% CI: 11.83 to 51.13) | 12.22 (95% CI: 2.53 to 21.91) | 0.0509 | 0.39 |
| Cladribine | 67.26 (95% CI: 28.1 to 106.4) | 40.15 (95% CI: 15.06 to 65.24) | 0.1703 | 0.60 |