TABLE 1

Cellular processes regulated by vasopressin in collecting duct principal cells

Vasopressin ActionsReferencesFig. 2 Cluster
Accelerates Aqp2 gene transcriptionHasler et al., 2009; Sandoval et al., 20161
Mobilizes intracellular calciumStar et al., 1988; Champigneulle et al., 1993; Chou et al., 20002
Reorganizes filamentous actinSimon et al., 1993; Tamma et al., 2001; Chou et al., 2004; Loo et al., 20133
Depolymerizes filamentous actinSimon et al., 1993; Tamma et al., 20014
Causes microtubule-dependent AQP2 redistributionSabolić et al., 19955
Accelerates exocytosis of AQP2-containing vesiclesNielsen and Knepper, 1993; Nielsen et al., 1995; Nunes et al., 20086
Decreases AQP2 endocytosisNielsen and Knepper, 1993; Brown, 20037
Increases tight junction permeabilityMishler et al., 19908
Accelerates AQP2 translationKhositseth et al., 2011; Sandoval et al., 20139
Increases AQP2 protein half-lifeNedvetsky et al., 2010; Sandoval et al., 201311
Slows rate of apoptosisMiller et al., 201310
Slows rate of proliferationYamaguchi et al., 2003
Increases principal cell sizeGanote et al., 1968; Kirk et al., 1984; Nielsen et al., 1993; Chou et al., 2008