Voltage-dependent inactivation parameters of INa among Nav1.5 ethnicity-related polymorphisms obtained using Boltzmann equation fitted to the data.
Kolmogorov-Smirnov test, two-way ANOVA followed by Tukey's post-test.
| AMIO (−) | AMIO (−) | AMIO (+) | AMIO (+) | |
|---|---|---|---|---|
| Slope | Vh (mV) | Slope | Vh (mV) | |
| WT (n = 11) | 5.1 ± 0.7 | −75.9 ± 3.7 | 6.4 ± 0.5** | −87.3 ± 6.3** |
| S524Y (n = 7) | 4.6 ± 0.6 | −74.9 ± 4.1 | 5.7 ± 0.6 | −83.9 ± 4.1** |
| S1103Y (n = 5) | 5.2 ± 0.6 | −78.8 ± 3.8 | 7.1 ± 1.3** | −89.4 ± 5.9** |
| R1193Q (n = 7) | 4.7 ± 0.6 | −76.8 ± 1.9 | 5.5 ± 0.8 | −84.6 ± 2.3** |
| V1951L (n = 7) | 5.1 ± 0.5 | −77.9 ± 2.2 | 5.7 ± 0.3 | −86.3 ± 1.2** |
Vh, voltage in which half of the maximum channel availability is achieved.
↵** P < 0.05, comparing (−) AMIO vs. (+) AMIO.