TABLE 1

Plasma concentrations of metformin and sorafenib. Values are medians (IQR); significances between sorafenib, concomitant, and sequential groups were tested using Kruskal-Wallis test.

	Metformin		Sorafenib
	2 h	4 h	2 h	6 h
		mg/l
Monotherapy (n = 3)	0.56 (0.36–0.73)	0.22 (0.18–0.49)	2.98 (1.34–3.23)	0.61 (0.61–0.77)
Concomitant (n = 4)			2.04 (1.84–3.08)	1.06 (0.63–1.38)
Sequential^a (n = 4)			2.07 (1.68–5.22)
Sequential^b (n = 3)			3.16 (2.03–5.20)

^aMetformin was administered 2 h before sorafenib.
^bMetformin was administered 4 h before sorafenib.