Pharmacokinetic parameters of deacetyldiltiazem after oral administration of diltiazem
The dose of diltiazem was 15 mg/kg (p.o.). Results were mean ± S.D. of six rats.
| Parameters | Unit | WT Rats | KO Rats |
|---|---|---|---|
| t1/2 | H | 2.94 ± 0.72 | 2.45 ± 0.27 |
| tmax | H | 0.25 | 0.50 |
| Cmax | ng/ml | 438.75 ± 138.04 | 5.69 ± 3.27*** |
| AUC0-24h | h*ng/ml | 597.89 ± 91.89 | 15.66 ± 4.52*** |
| AUC0-inf | h*ng/ml | 598.09 ± 92.01 | 15.74 ± 4.52*** |
| MRT0-24h | H | 1.59 ± 0.12 | 2.83 ± 0.44** |
MRT, mean residence time; tmax, peak time .
**P < 0.01 and ***P < 0.001 compared with WT rats.