Effects of KN-93 or chelerythrine on diastolic Ca2+ level and transient decay time constant in the absence and presence of chrysosplenol-C in rat ventricular myocytes
Data represent mean ± S.D. The number in the parenthesis indicates number of cells. Paired t tests were done. Considering the new p value after the Bonferroni correction, p value less than 0.0125 (0.05/4) was considered to be significant.
| Diastolic [Ca2+] (F/F0) | Decay (τ, ms) | n | |
|---|---|---|---|
| Control | 1 | 156 ± 52 | 12 |
| KN-93 | 1.02 ± 0.0045 | 160 ± 51 | 12 |
| KN-93 + CP-C | 1.07 ± 0.026* | 162 ± 76 | 12 |
| Control | 1 | 165 ± 34 | 8 |
| Chel | 1.06 ± 0.013 | 168 ± 44 | 8 |
| Chel + CP-C | 1.05 ± 0.018 | 169 ± 54 | 8 |
Chel, chelerythrine (2 μM); CP-C. chrysosplenol-C.