TARP Effect | Drug Effect | |||||
---|---|---|---|---|---|---|
Control | upMD [95% CI] | P value | +JNJ-118 | pMD [95% CI] | P value | |
τw, deact (ms) | ||||||
GluA2 | 0.41 ± 0.07 (7) | – | – | 0.45 ± 0.13 (7) | 0.044 [−0.003, 0.17] | 0.48 |
GluA2/γ8 | 1.34 ± 0.61 (9) | 0.93 [0.64, 1.45] | 0.0019 | 0.93 ± 0.47 (9) | −0.42 [−0.58, −0.27] | 0.023 |
GluA2/γ8.dm | 1.12 ± 0.58 (7) | 0.72 [0.45, 1.36] | 0.0052 | 1.05 ± 0.52 (7) | −0.071 [−0.14, 0.007] | 0.48 |
GluA2/γ2 | 1.98 ± 1.87 (10) | 1.57 [0.67, 2.88] | 0.0012 | 1.79 ± 1.50 (10) | −0.19 [−0.5, 0.018] | 0.48 |
GluA2/γ2.dm | 1.34 ± 1.35 (12) | 0.93 [0.47, 2.35] | 0.010 | 0.3 ± 0.98 (12) | −0.41 [−0.74, −0.26] | 0.0049 |
τw, des (ms) | ||||||
GluA2 | 5.6 ± 0.9 (16) | – | – | 5.0 ± 1.0 (16) | −0.54 [−1.19, 0.12] | 0.30 |
GluA2/γ8 | 10.6 ± 3.1 (19) | 5.04 [3.81, 6.75] | <0.0001 | 7.8 ± 2.1 (19) | −2.78 [−4.74, −1.39] | <0.0001 |
GluA2/γ8.dm | 10.3 ± 5.1 (16) | 4.78 [2.88, 8.17] | <0.0001 | 9.7 ± 3.5 (16) | −0.62 [−4.10, 1.88] | 1.00 |
GluA2/γ2 | 12.3 ± 5.0 (18) | 6.75 [4.81, 9.4] | <0.0001 | 12.3 ± 6.0 (18) | 0.017 [−3.07, 4.13] | 1.00 |
GluA2/γ2.dm | 12.0 ± 5.0 (19) | 6.4 [4.63, 9.47] | <0.0001 | 5.5 ± 1.7 (19) | −6.44 [−9.61, −4.60] | <0.0001 |
Iss/Ipeak (%) | ||||||
GluA2 | 1.17 ± 1.16 (16) | – | – | 0.90 ± 0.65 (16) | −0.27 [−0.68, −0.023] | 0.65 |
GluA2/γ8 | 4.51 ± 4.02 (19) | 3.35 [1.73, 5.53] | 0.0047 | 2.74 ± 1.83 (19) | −1.78 [−3.32, -0.78] | 0.049 |
GluA2/γ8.dm | 4.88 ± 6.23 (16) | 3.71 [1.55, 8.56] | 0.022 | 4.30 ± 5.74 (16) | −0.58 [−1.49, 0.074] | 0.53 |
GluA2/γ2 | 8.09 ± 6.55 (18) | 6.92 [4.78, 11.6] | <0.0001 | 7.95 ± 5.89 (18) | −0.14 [−1.19, 0.86] | 0.83 |
GluA2/γ2.dm | 6.98 ± 4.42 (19) | 5.81 [4.05, 8.11] | <0.0001 | 3.26 ± 2.31 (19) | −3.72 [−5.47, −2.05] | 0.0047 |
τrec (ms) | ||||||
GluA2 | 13.6 ± 2.5 (6) | – | – | 15.6 ± 4.1 (6) | 2.02 [0.61, 4.37] | 0.55 |
GluA2/γ8 | 69.8 ± 14.1 (10) | 56.2 [47.3, 64.3] | 0.0032 | 62.1 ± 18.5 (10) | −7.8 [−14.3, 0.62] | 0.55 |
GluA2/γ8.dm | 59.7 ± 15.2 (8) | 46.1 [38.8, 60.4] | 0.0073 | 56.9 ± 29.6 (8) | −2.85 [−9.9, 15.3] | 0.59 |
GluA2/γ2 | 21.1 ± 7.1 (7) | 7.47 [2.67, 12.8] | 0.13 | 17.3 ± 3.4 (7) | −3.77 [−9.09, −1.16] | 0.55 |
GluA2/γ2.dm | 18.8 ± 3.2 (6) | 5.22 [2.47, 8.38] | 0.13 | 16.2 ± 2.5 (6) | −2.59 [−5.16, −0.25] | 0.55 |