Table 5

Ca2+-activated tension parameters for skinned fiber bundles of 14-day-old TG-cTnT-R92Q mice and NTG controls treated with 0.3 µM Mava

Data are presented as mean ± S.D. Two-way ANOVA test followed with a Tukey’s multiple comparison post hoc test.

Skinned FibersTreatmentMax Tension (mN/mm2)pCa50Hill Slope
NTG 14d (n = 4)Control26.49 ± 4.205.73 ± 0.025.04 ± 0.69
NTG 14d (n = 4)Mava 0.3 µM13.30 ± 2.90a5.59 ± 0.045.62 ± 0.37b,c
TG-cTnT-R92Q 14d (n = 5)Control24.93 ± 4.83d5.94 ± 0.06e,f2.71 ± 0.34g
TG-cTnT-R92Q 14d (n = 5)Mava 0.3 µM13.97 ± 2.97h,i5.75 ± 0.11j,k3.44 ± 0.57l
  • aP = 0.0013, 95% CI of diff. [5.29 to 21.09] when compared with NTG 14-day control

  • bP < 0.0001, 95% CI of diff. [−3.91 to −1.92] when compared with TG-cTnT-R92Q 14-day control

  • cP < 0.0001, 95% CI of diff. [−3.17 to −1.18] when compared with TG-cTnT-R92Q 14-day 0.3 µM Mava

  • dP = 0.0024, 95% CI of diff. [−19.13 to −4.14] when compared with NTG 14-day 0.3 µM Mava

  • eP = 0.0022, 95% CI of diff. [−0.34 to −0.07] when compared with NTG 14-day control

  • fP < 0.0001, 95% CI of diff. [−0.48 to −0.22] when compared with NTG 14-day 0.3 µM Mava

  • gP < 0.0001, 95% CI of diff. [−3.33 to −1.34] when compared with NTG 14-day control

  • hP = 0.0025, 95% CI of diff. [3.89 to 18.03] when compared with TG-cTnT-R92Q 14-day control

  • iP = 0.0013, 95% CI of diff. [5.02 to 20.01] when compared with NTG 14-day control

  • jP = 0.0162, 95% CI of diff. [−0.29 to −0.03] when compared with NTG 14-day 0.3 µM Mava

  • kP = 0.0034, 95% CI of diff. [0.06 to 0.31] when compared with TG-cTnT-R92Q 14-day control

  • lP = 0.0018, 95% CI of diff. [−2.59 to −0.60] when compared with NTG 14-day control