Table 1

Ca2+-activated tension parameters for skinned fibers of adult TG-ssTnI mice and NTG controls treated with 0.3 µM OM

Data are presented as mean ± S.D. Two-way ANOVA test followed by a Tukey’s multiple comparison post hoc test.

Skinned FibersTreatmentMax Tension (mN/mm2)pCa50Hill Slope
NTG adult (n = 5)Control33.50 ± 3.075.73 ± 0.035.65 ± 0.30
NTG adult (n = 5)OM 0.3 µM31.12 ± 3.225.89 ± 0.08a2.49 ± 0.69b
TG-ssTnI adult (n = 5)Control26.62 ± 2.75c5.94 ± 0.05d3.12 ± 0.36e
TG-ssTnI adult (n = 5)OM 0.3 µM26.66 ± 4.71f6.07 ± 0.07g,h,i1.96 ± 0.21j,k
  • aP = 0.0035, 95% confidence interval (CI) of diff. [-0.27 to -0.05] when compared with NTG adult control

  • bP < 0.0001, 95% CI of diff. [−3.94 to −2.39] when compared with NTG adult control

  • cP = 0.0319, 95% CI of diff. [0.51 to 13.24] when compared with NTG adult control

  • dP = 0.0002, 95% CI of diff. [−0.32 to −0.10] when compared with NTG adult control

  • eP < 0.0001, 95% CI of diff. [−3.30 to −1.76] when compared with NTG adult control

  • fP = 0.0329, 95% CI of diff. [0.48 to 13.21] when compared with NTG adult control

  • gP = 0.0164, 95% CI of diff. [−0.24 to −0.02] when compared with TG-ssTnI adult control

  • hP = 0.001, 95% CI of diff. [−0.29 to −0.07] when compared with NTG adult 0.3 µM OM

  • iP < 0.0001, 95% CI of diff. [−0.45 to −0.24] when compared with NTG adult control

  • jP = 0.0027, 95% CI of diff. [−1.94 to −0.39] when compared with TG-ssTnI adult control

  • kP < 0.0001, 95% CI of diff. [−4.47 to −2.92] when compared with NTG adult control