TABLE 1

Peak current block by JNJ-118 of GluA2 coexpressed with wild-type or mutated forms of γ8 and γ2

Summary of peak current block (I118/ICtrl), presented as mean ± S.D. from (n) patches. To assess the extent of inhibition, one-sample Wilcoxon signed-rank tests (against 100%) were used. For TARP effects, unpaired mean differences (upMD; GluA2+TARP versus GluA2 alone) with 95% confidence intervals (lower bound, upper bound), and P values from Wilcoxon rank-sum tests are shown. For pairwise tests, the P values were adjusted for multiple comparisons using Holm’s sequential Bonferroni correction.

I118/ICtrl (%)Compared with 100%Compared with GluA2
P valueupMD [95% CI]P value
GluA294.5 ± 19.5 (16)0.77
GluA2/γ859.5 ± 12.9 (19)<0.0001−35.0 [−46.8, −25.1]<0.0001
GluA2/γ8.dm96.6 ± 12.9 (16)0.772.1 [−10.1, 12.2]0.54
GluA2/γ298.2 ± 7.2 (18)0.773.7 [−6.5, 13.0]0.18
GluA2/γ2.dm45.8 ± 8.7 (19)<0.0001−48.8 [−59.5, −39.7]<0.0001