TABLE 1

The weighted hydrogen-bond scores H (see eqs. 1 and 2 for details) in descending order for residues in the N-terminal domain of FGF23 that form hydrogen bonds with ZINC13407541, 13a, and 8n in the molecular docking

ZINC13407541		13a		8n
Residue	H	Residue	H	Residue	H
Gln156	0.417	Tyr93	0.293	Tyr93	0.159
Asn122	0.408	Gln156	0.278	Gln156	0.143
Arg76	0.242	Asn122	0.207	Thr86	0.096
Ser77	0.159	Thr86	0.120	Tyr154	0.091
Tyr93	0.134	Arg76	0.113	Ser137	0.074
Thr86	0.115	Ser77	0.101	Gly139	0.074
Met74	0.083	Met74	0.078	Thr46	0.063
Val84	0.083	Val84	0.078	Asn49	0.063
Leu146	0.027	Ala45	0.035	Ser77	0.063
Ile75	0.024	Gln67	0.031	Arg76	0.061
Gly38	0.012	Leu146	0.021	Ser155	0.052
Glu78	0.009	Asn49	0.015	Ile75	0.047
Ser159	0.009	Pro152	0.015	Leu146	0.045
Gln118	0.007	Tyr154	0.015	Met74	0.033
Thr119	0.007	Ser155	0.015	Val84	0.033
				Ser34	0.024
				Gly38	0.024
				Pro152	0.024
				Asn162	0.024
				Ile164	0.024
				Asp125	0.020
				Tyr127	0.020
				Ser159	0.020

Ala, Alanine; Arg, Arginine; Asn, Asparagine; Asp, Aspartic acid; Glu, Glutamic acid; Gly, Glycine; Ile, Isoleucine; Leu, Leucine; Met, Methionine; Pro, Proline; Ser, Serine; Thr, Threonine; Tyr, Tyrosine; Val, Valine.