TABLE 1

The weighted hydrogen-bond scores H (see eqs. 1 and 2 for details) in descending order for residues in the N-terminal domain of FGF23 that form hydrogen bonds with ZINC13407541, 13a, and 8n in the molecular docking

ZINC1340754113a8n
ResidueHResidueHResidueH
Gln1560.417Tyr930.293Tyr930.159
Asn1220.408Gln1560.278Gln1560.143
Arg760.242Asn1220.207Thr860.096
Ser770.159Thr860.120Tyr1540.091
Tyr930.134Arg760.113Ser1370.074
Thr860.115Ser770.101Gly1390.074
Met740.083Met740.078Thr460.063
Val840.083Val840.078Asn490.063
Leu1460.027Ala450.035Ser770.063
Ile750.024Gln670.031Arg760.061
Gly380.012Leu1460.021Ser1550.052
Glu780.009Asn490.015Ile750.047
Ser1590.009Pro1520.015Leu1460.045
Gln1180.007Tyr1540.015Met740.033
Thr1190.007Ser1550.015Val840.033
Ser340.024
Gly380.024
Pro1520.024
Asn1620.024
Ile1640.024
Asp1250.020
Tyr1270.020
Ser1590.020
  • Ala, Alanine; Arg, Arginine; Asn, Asparagine; Asp, Aspartic acid; Glu, Glutamic acid; Gly, Glycine; Ile, Isoleucine; Leu, Leucine; Met, Methionine; Pro, Proline; Ser, Serine; Thr, Threonine; Tyr, Tyrosine; Val, Valine.