TABLE 5

Gene-expression profiles in kidney of Hyp mice treated with ZINC13407541 and its analogs (n = 5–6)

Data are expressed as the fold changes relative to the housekeeping gene β-actin subsequently normalized to control mice. *, **, and *** indicate statistically significant difference from vehicle control group. P values were determined by one-way ANOVA with Tukey’s multiple-comparisons test.

GeneVehicle
(n = 6)
ZINC13407541
(n = 6)
8n
(n = 6)
13a
(n = 5)
p-Value
Fgfr11.00 ± 0.190.98 ± 0.150.95 ± 0.130.90 ± 0.290.8270
Npt2a1.00 ± 0.101.36 ± 0.15*1.44 ± 0.19*1.76 ± 0.44***0.0007
Npt2c1.00 ± 0.131.37 ± 0.15*1.41 ± 0.11**1.98 ± 0.48***<0.0001
Klotho1.00 ± 0.121.32 ± 0.16*1.34 ± 0.16*1.66 ± 0.22***<0.0001
Cyp24a11.00 ± 0.100.69 ± 0.15**0.64 ± 0.11***0.66 ± 0.16***0.0004
Cyp27b11.00 ± 0.101.42 ± 0.14*1.48 ± 0.14*2.08 ± 0.61***0.0001
NCC1.00 ± 0.150.64 ± 0.13***0.72 ± 0.17**0.55 ± 0.12***0.0002