Gene-expression profiles in kidney of Hyp mice treated with ZINC13407541 and its analogs (n = 5–6)
Data are expressed as the fold changes relative to the housekeeping gene β-actin subsequently normalized to control mice. *, **, and *** indicate statistically significant difference from vehicle control group. P values were determined by one-way ANOVA with Tukey’s multiple-comparisons test.
| Gene | Vehicle (n = 6) | ZINC13407541 (n = 6) | 8n (n = 6) | 13a (n = 5) | p-Value |
|---|---|---|---|---|---|
| Fgfr1 | 1.00 ± 0.19 | 0.98 ± 0.15 | 0.95 ± 0.13 | 0.90 ± 0.29 | 0.8270 |
| Npt2a | 1.00 ± 0.10 | 1.36 ± 0.15* | 1.44 ± 0.19* | 1.76 ± 0.44*** | 0.0007 |
| Npt2c | 1.00 ± 0.13 | 1.37 ± 0.15* | 1.41 ± 0.11** | 1.98 ± 0.48*** | <0.0001 |
| Klotho | 1.00 ± 0.12 | 1.32 ± 0.16* | 1.34 ± 0.16* | 1.66 ± 0.22*** | <0.0001 |
| Cyp24a1 | 1.00 ± 0.10 | 0.69 ± 0.15** | 0.64 ± 0.11*** | 0.66 ± 0.16*** | 0.0004 |
| Cyp27b1 | 1.00 ± 0.10 | 1.42 ± 0.14* | 1.48 ± 0.14* | 2.08 ± 0.61*** | 0.0001 |
| NCC | 1.00 ± 0.15 | 0.64 ± 0.13*** | 0.72 ± 0.17** | 0.55 ± 0.12*** | 0.0002 |