Serum biochemistry of Hyp mice treated with ZINC13407541 and its analogs
Data are expressed as the mean ± S.D. from serum samples of individual mice (n = 5–8). *, **, and *** indicate statistically significant difference from vehicle control group. P values were determined by one-way ANOVA with Tukey’s multiple-comparisons test.
| Parameters | Vehicle (n = 7) | ZINC13407541 (n = 8) | 8n (n = 8) | 13a (n = 5) | p-Value |
|---|---|---|---|---|---|
| FGF23 (pg/ml) | 1413 ± 366 | 2359 ± 861* | 1754 ± 445 | 1378 ± 289 | 0.0110 |
| Phosphate (mg/dl) | 4.6 ± 0.60 | 6.5 ± 1.02** | 6.7 ± 0.58** | 7.8 ± 1.08*** | <0.0001 |
| Calcium (mg/dl) | 8.0 ± 1.23 | 8.9 ± 1.22 | 8.4 ± 1.77 | 8.3 ± 1.63 | 0.7208 |
| PTH (pg/ml) | 78 ± 12 | 122 ± 21** | 118 ± 20** | 138 ± 21*** | 0.0002 |
| 1,25(OH)2D (pg/ml) | 19 ± 13 | 65 ± 14*** | 69 ± 19*** | 116 ± 14*** | <0.0001 |
| Aldosterone (pg/ml) | 278 ± 84 | 389 ± 68* | 401 ± 113* | 497 ± 71*** | 0.0031 |