TABLE 3

Serum biochemistry of Hyp mice treated with ZINC13407541 and its analogs

Data are expressed as the mean ± S.D. from serum samples of individual mice (n = 5–8). *, **, and *** indicate statistically significant difference from vehicle control group. P values were determined by one-way ANOVA with Tukey’s multiple-comparisons test.

ParametersVehicle
(n = 7)
ZINC13407541
(n = 8)
8n
(n = 8)
13a
(n = 5)
p-Value
FGF23 (pg/ml)1413 ± 3662359 ± 861*1754 ± 4451378 ± 2890.0110
Phosphate (mg/dl)4.6 ± 0.606.5 ± 1.02**6.7 ± 0.58**7.8 ± 1.08***<0.0001
Calcium (mg/dl)8.0 ± 1.238.9 ± 1.228.4 ± 1.778.3 ± 1.630.7208
PTH (pg/ml)78 ± 12122 ± 21**118 ± 20**138 ± 21***0.0002
1,25(OH)2D (pg/ml)19 ± 1365 ± 14***69 ± 19***116 ± 14***<0.0001
Aldosterone (pg/ml)278 ± 84389 ± 68*401 ± 113*497 ± 71***0.0031