TABLE 1

IC50 values for inhibition by ImKTX58 and its mutants on KV1.3

NameIC50 (nM)SDNormalized IC50 to WTSample Number
ImKTX58-WT10.41.517
ImKTX58-R24A949.948.891.29
ImKTX58-H26A109.811.810.55
ImKTX58-K28A>10μM>959.95
ImKTX58-M30A75.24.97.28
ImKTX58-N31A1613.4231.0154.98
ImKTX58-K32A277.043.526.65
ImKTX58-Y37A496.723.647.75