TABLE 1

Some human cancers and the most-known driver genes amplified in eccDNA/gene duplications

For more details, see references (Aguirre et al., 2016; Munoz et al., 2016; Hull et al., 2017; Lanciano et al., 2017; Gonçalves et al., 2019; Kumar et al., 2020).

Cancer TypesAssociated Driver Genes
Adrenocortical carcinomaEGFR, FGFR2, KIT, FOXA1, NFE2L2, SOS1, H3F3A, PCBP1, PMS1, SF3B1,
Breast invasive carcinomaEGFR, FGFR2, KIT, FOXA1, MYC, WT1, KRAS, H3F3A, CCND1, PIK3CG, PIK3R2, AKT1, MTOR, SF1, PTPRC, PTPN11, ERCC2, MSH3, ERBB2, ERBB3, SOX17
Colon adenocarcinomaEGFR, FGFR2, CDK4, FOXA1, KRAS, WT1, H3F3A, CCND1, PIK3CG, PIK3CA, PIK3R2, MTOR, SF1, PTPRC, KLF5, ERCC2, ERBB2, ERBB3, SOX17
Brain Lower Grade GliomaWT1, KIT, PIK3CG, MTOR, MACF1, PCBP1
Glioblastoma multiformeEGFR, MYC, CDK4, PIK3R2, ERCC2, GRIN2D, H3F3A,
Kidney renal papillary cell carcinomaEGFR, FGFR2, MYC, FOXA1, PIK3CG, PIK3CA, PTPRC, ERCC2, ERBB2, SOX17
Liver hepatocellular carcinomaWT1, KIT, CDKN1A, CCND1, PIK3CG, PIK3CA, PIK3R2, KRAS, SF1, DHX9, PTPRC, PTPN11, ERCC2, SOS1, ERBB2
Kidney renal clear cell carcinomaWT1, FGFR2, KRAS, MTOR, FOXA1, PIK3CG, PIK3R2, PTPRC, CDK4, ERCC2, SOS1, ERBB2, ERBB3, SOX17
Lung adenocarcinomaMYC, WT1, FGFR2, KRAS, MTOR, PIK3R2, SF1, H3F3A, PTPRC, CDK4, CCND1, ERCC2, SOS1, ERBB2, ERBB3
Stomach adenocarcinomaMYC, WT1, EGFR, KRAS, NRAS, MTOR, PIK3CA, PIK3R2, H3F3A, SF1, CDK4, CCND1, ERBB2, ERBB3, SOX17
Skin Cutaneous MelanomaEGFR, KRAS, FOXA1, PIK3R2, CCND1, ERCC2
Thyroid carcinomaNRAS, PIK3CG, KLF5, ERCC2, ERBB2
Uterine Corpus Endometrial CarcinomaPIK3CG, PIK3R2, PIK3CA, KLF5, CCND1, ERBB2
Prostate adenocarcinomaEGFR, MYC, KRAS, KIT, MTOR, FOXA1, PIK3CG, PIK3R2, CDK4, ERCC2, ERBB2, ERBB3, SOX17
Lung squamous cell carcinomaFGFR3, NRAS, KRAS, PTPN11, H3F3A, CDK4, ERCC2, SOS1, PCBP1, ERBB3