Table 2

Effects of kinases on SLC transporters

TransporterKinase involvedEffect on transporter
(Phosphorylation sites)
References
OAT1
(SLC22A6)
PKCAccelerates internalization and reduces transport functionZhang et al., 2008
PKCζActivation by insulin or EGF leads to induced transport functionBarros et al., 2009
SGK2Associates with OAT1, increases its stability and activityXu et al., 2016a
OAT3
(SLC22A8)
PKCReduces cell surface protein level by increasing endocytosis of the transporterDuan et al., 2010
PKCζInteracts with OAT3 and kinase activation leads to induce transport functionBarros et al., 2009
PKAActivation by IGF-1 increases phosphorylation, protein level and function of the transporterZhang et al., 2020
OCT2
(SLC22A2)
PKA
PI3K
CaMKII/MLCK
Activator suppresses transport function
Inhibitor increases transport function
Inhibitor reduces transport function
Cetinkaya et al., 2003
Yes-1Associates and phosphorylates OCT2, inhibitor suppresses transport function
(Tyr241, Tyr362 (major site) and Tyr377)
Sprowl et al., 2016
OATP1B1
(SLCO1B1)
PKCAffects both internalization and recycling of OATP1B1, results in reduce membrane expression and transport activityHong et al., 2015
LynPhosphorylates OATP1B1, inhibitor suppresses transport function (possibly Tyr645)Hayden et al., 2021
OATP1B3
(SLCO1B3)
PKCAffects phosphorylation level and reduces function of the transporterPowell et al., 2014
MATE1
(SLC47A1)
p56lck
CK2
Inhibitor reduces uptake function
Inhibitor stimulates uptake function but inhibits efflux function (possibly Ser402)
Kantauskaitė et al., 2020
MATE2(K)
(SLC47A2)
p56lck
CK2
PKA/PKC
Inhibitor induces uptake function (possibly Tyr104)
Inhibitor stimulates uptake function (possibly Ser3, Ser508 and Ser519)
Activators reduce efflux function
Kantauskaitė et al., 2020