TABLE 1
Physicochemical profiles of tepotinib, crizotinib, capmatinib, and savolitinib
| Compound | Structure | MW [g/mol] | HAc [N] | HDon [N] | TPSA [Å2] | logP | pKa1 | pKa2 |
|---|---|---|---|---|---|---|---|---|
| Tepotinib |  | 492.58 | 8 | 0 | 95 | 3.99 | 9.25 | — |
| Crizotinib |  | 450.34 | 6 | 3 | 78 | 3.87 | 9.21 | 5.29 |
| Capmatinib |  | 412.43 | 7 | 1 | 85 | 2.36 | 4.57 | 2.18 |
| Savolitinib |  | 345.37 | 9 | 0 | 92 | 1.28 | 5.80 | — |
HAc, hydrogen bond acceptors; HDon, hydrogen bond donators; MW, molecular weight; TPSA, topological polar surface area.