TABLE 1

Selected molecules involved in the regulation of ferroptosis

Molecule	Regulation	Promote/Inhibit Ferroptosis	Reference
SCD1	[Inhibition] Desaturation of saturated fatty acids—competitive formation of monounsaturated fatty acids	Promote	Luis et al., 2021
CD 36	[Upregulation] Increase in the import of fatty acids into cells	Promote	Pizon et al., 2018
Transferin receptor	[Upregulation] Increase in unstable iron pool	Promote	Yang and Stockwell, 2008
FABP	[Inhibition] Creation of lipid droplets in cells	promote
Heat shock protein β-1	[Knockdown] Increase in iron uptake	Promote	Sun et al., 2015
FANCD2	[Knockdown] Increase in iron uptake	Promote	Song et al., 2016
Ferritin heavy chain 1	[Knockdown] Reduction in the content of iron-binding proteins in the cell	Promote	Yang and Stockwell, 2008
Heme oxygenase	[Upregulation] Enhancement of heme catabolism and iron release	Promote	Kwon et al., 2015
SGLT2	[Inhibition] Increase in AMPK phosphorylation	Promote	Zhou et al., 2020b
Erastin/sorafenib	[Increase in concentration] Blockage of system x_c^-	Promote	Lin et al., 2020
Iron response element-binding protein 2	[Knockdown] Regulation of RNA translation responsible for iron consumption	Inhibit	Dixon et al., 2012
NCOA4	[Knockdown] Slowdown in the degradation of ferritin in the process of autophagy	Inhibit	Mancias et al., 2014
Ferroportin	[Upregulation] Increase in transport of iron outside the cell	Inhibit	Wang et al., 2018
Autophagy-related protein 3	[Knockdown] Slowdown in the degradation of ferritin in the process of autophagy	Inhibit	Gao et al., 2016