TABLE 1

IC50 values of data show in Fig. 1B for iperoxo to displace 3H-NMS (1 nM) at the M3R in the presence of the indicated G protein heterotrimer or vehicle N = 3 replicates per condition for Gq, Gi, Gs, and G13 conditions; N = 6 replicates for vehicle condition.

Log(IC50)Standard Error
Gq−8.51.2
Gi−6.70.79
Gs−5.50.51
G13−4.30.12
Vehicle−4.50.05