TABLE 1

Target proteins activated by calmodulin and inhibited by melatonin

Target Proteins Activated by CaMMelatonin IC50 [M]Calmodulin Antagonists IC50 [M]Reference
cAMP-Phosphodiesterase Activity1 × 10−9Trifluoperazine 1 × 10−5Benítez-King et al., 1991
Tubulin Polymerization1 × 10−9Trifluoperazine 1 × 10−5Huerto-Delgadillo et al., 1994
Compound 48/80 1 μg/ml
CAMKII Activity1 × 10−5Trifluoperazine 1 × 10−5 (40% Inhibition)Benítez-King et al., 1996
CaMKII Autophosphorylation1 × 10−9W7 1 × 10−5 (42% Inhibition)
Compound 48/80 30 ug/ml (92% Inhibition)
Nitric Oxide Synthase Activity1 × 10−8Non-ReportedPozo et al., 1994
Calcineurin Activity1 × 10−4-1 × 10−3 (30% Inhibition)Non-ReportedOuyang and Vogel, 1998
Estrogen receptor alpha (ER-α) response1.26 × 10−11W7 1 × 10−7
Calmidazolium 1 × 10−7
Del Río et al., 2004
Rat myotube-acetylcholine receptors responses mediated by CaM dependent adenylyl cyclase0.19 × 10−9Calmidazolium 5 × 10−5De Almeida-Paula 2005