Regular ArticleThe Guinea Pig Histamine H2 Receptor: Gene Cloning, Tissue Expression and Chromosomal Localization of Its Human Counterpart
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Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice
2014, NeuronCitation Excerpt :The inhibitory H3 receptor is expressed presynaptically on dopaminergic terminals and may explain the ability of HA to reduce striatal DA, but it is also expressed presynaptically on other cell types and regulates other neurotransmitters (Ellender et al., 2011; Haas et al., 2008; Schlicker et al., 1994). HA H1 and H2 receptors are also expressed prominently in the basal ganglia circuitry and throughout the brain (Haas et al., 2008; Traiffort et al., 1994; Traiffort et al., 1995; Zhou et al., 2006). How alterations in information processing beyond the basal ganglia contribute to pathophysiological changes relevant to TS is an important area for future study.
Regulation of the immune response and inflammation by histamine and histamine receptors
2011, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Murine H1R knockout models have revealed significant immunologic (impairment of T- and B-cell responses), metabolic, and behavioral abnormalities.36-38 The human H2R is a 40-kd 359-amino-acid protein encoded by an intronless gene located on chromosome 5q35.5, and human H2R shows a high sequence homology (83% to 95% identity) to other species (guinea pig, mouse, rat, and dog).39,40 Similar to H1R, expression of H2R is found in a variety of tissues and cells, including the brain, gastric parietal cells, smooth muscle cells, T and B cells, DCs, and cardiac tissue.
Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis
2010, NeuropharmacologyCitation Excerpt :In addition to cGMP production, H1R stimulation can lead to generation of cAMP, and it means that H1R can also couple to Gs protein (Leurs et al., 1994; Baudry et al., 1975; Daum and Young, 1982; Richelson, 1978). The gene that encodes human H2R is located on chromosome 5 and its product is the seven transmembrane GPCR (Traiffort et al., 1995). H2Rs, expressed in the periphery and in the CNS couple to Gs proteins.
Expression of a G protein-coupled receptor (GPCR) leads to attenuation of signaling by other GPCRs: Experimental evidence for a spontaneous GPCR constitutive inactive form
2010, Journal of Biological ChemistryCitation Excerpt :However, in genetically engineered systems where receptors can be expressed at high densities, Costa and Herz (2) noted that high levels of receptor expression uncovered the existence of a population of spontaneously (unliganded) active receptors, resulting in an elevated basal response in the system. The histamine H2 receptor (H2R) is an extensively characterized member of the GPCR family, which in most systems couples to Gs proteins to activate adenylyl cyclase (3–6). Compared with other GPCRs, the H2R is unique in that the wild-type receptor possesses a remarkably high degree of constitutive activity.
Anxiety-like behavior induced by histaminergic agents can be prevented by cannabinoidergic WIN55,212-2 injected into the dorsal hippocampus in mice
2010, Pharmacology Biochemistry and BehaviorThe effects of histaminergic agents in the dorsal hippocampus of rats in the elevated plus-maze test of anxiety
2006, Pharmacology Biochemistry and Behavior