Biochemical and Biophysical Research Communications
Regular ArticleMolecular Cloning, Sequence, and Expression Patterns of the Human Gene Encoding CCAAT/Enhancer Binding Protein α (C/EBPα)
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Novel insights of acute myeloid leukemia with CEBPA deregulation: Heterogeneity dissection and re-stratification
2021, Critical Reviews in Oncology/HematologyCitation Excerpt :The gene coding for CEBPα is located on chromosome 19q13.1. It has no introns and encodes 2783 base pairs (Birkenmeier et al., 1989; Antonson and Xanthopoulos, 1995). The mRNA-encoding CEBPα contains three AUGs sharing a common open reading frame (ORF), and alternative translation initiation can give rise to two protein isoforms.
Functionally analyzing the important roles of hepatocyte nuclear factor 3 (FoxA) in tumorigenesis
2020, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :It is noted that the GATA3 has closely relationship with FoxA1 in hormone-dependent cancers, such as breast and prostate cancers, however, whether other members of GATA with similar function as GATA3, and the potential function of GATA/FoxAs in other carcinomas, are still unknown. The human transcription factor C/EBPα has been initially isolated from umbilical cord genomic library [166], while the mouse gene encoding C/EBP has three alleles which are identified on the restriction fragment length polymorphisms [167]. C/EBPα expression was tissue-specific and expressed highest in placenta while a relative high expression in tissues such as liver, lung, skeletal muscle and pancreas [166].
A comparison of two methods for screening CEBPA mutations in patients with acute myeloid leukemia
2009, Journal of Molecular DiagnosticsCitation Excerpt :Therefore, fragment analysis alone is not a thorough way to screen for CEBPA mutation in AML patients. Additional problems with the published fragment length assay are the lack of full coverage of the coding region of CEBPA (a GC-rich region of the gene is omitted), and the possibility of missing insertion or deletion mutations if they lie at the sites of PCR primer binding.16 Given that mutations are spread through all areas of the CEBPA gene, some clinically relevant mutations may be present in regions of the gene that are not analyzed using this method.