Regular ArticleThe Human Vasoactive Intestinal Peptide/Pituitary Adenylate Cyclase Activating Peptide Receptor 1 (VPAC1): Constitutive Activation by Mutations at Threonine 343☆
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2006, Journal of Biological ChemistryCitation Excerpt :These were the starting point for the rational design of the TYY mutant described below. Four of these were eliminated, because mutational data either: linked them to increased G protein activation (Leu-275) (23-26) or to decreased sequestration (Tyr-326) (27, 28) or was insufficient (Asn-330 and Ala-134). By contrast, the remaining three residues had mutations shown to decrease G protein signaling in multiple receptors and with no data suggesting a decrease in internalization.
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Greeley, GH
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