Regular ArticleDifferential Membrane Antioxidant Effects of Immediate and Long-Term Estradiol Treatment of MCF-7 Breast Cancer Cells
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2012, Brain ResearchCitation Excerpt :In contrast, the ERβ agonist diarylpropionitrile (DPN), but not the ERα agonist PPT, protects against 2-VO-induced damage in mice (Carswell et al., 2004). Estradiol, ERα-specific agonists, and ERβ-specific agonists have all been shown to up-regulate the expression of the anti-apoptotic marker Bcl-2 resulting in improved cell survival (Alkayed et al., 2001; Dubal et al., 1999; Schor et al., 1999; Zhao et al., 2004). While pharmacologically targeting specific estrogen receptors is a valuable strategy to employ toward understanding the mechanisms through which estradiol exerts its protective effects, use of genetically-modified mice provides a particularly powerful, complementary approach.
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On leave from the Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, St. Petersburg, 194223, Russia.