Regular ArticleA Putative Prokaryote Voltage-Gated Ca2+ Channel with Only One 6TM Motif per Subunit☆,☆☆
References (28)
- et al.
Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions
Neuron
(1995) - et al.
Structural models of the transmembrane region of voltage-gated and other K+ channels in open, closed, and inactivated conformations
J. Struct. Biol.
(1998) - et al.
From worm to man: Three subfamilies of TRP channels
Trends Neurosci.
(2000) - et al.
Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption
J. Biol. Chem.
(1999) - et al.
Molecular identification of the apical Ca2+ channel in 1,25-dihydroxyvitamin D3-responsive epithelia
J. Biol. Chem.
(1999) - et al.
Molecular cloning, cDNA sequence analysis, and chromosomal localization of mouse Pkd2
Genomics
(1997) - et al.
Molecular properties of inositol 1,4,5-trisphosphate receptors
Cell Calcium
(1999) - et al.
Structural and functional characterization of the purified cardiac ryanodine receptor-Ca2+ release channel complex
J. Biol. Chem.
(1989) - et al.
Three-dimensional structure of ryanodine receptor isoform three in two conformational states as visualized by cryo-electron microscopy
J. Biol. Chem.
(2000) - et al.
Coassembly of Trp1 and Trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels
J. Biol. Chem.
(2000)
A localized interaction surface for voltage-sensing domains on the pore domain of a K+ channel
Neuron
Ionic Channels of Excitable Membranes
Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability
Mol. Biol. Evol.
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Abbreviation used: 6TM, 6-transmembrane segment.
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