Regular ArticleDifferential Expression of Signal Transducers and Activators of Transcription during Human Adipogenesis
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2023, International ImmunopharmacologyInhibition of STAT3 enhances UCP1 expression and mitochondrial function in brown adipocytes
2022, European Journal of PharmacologyApigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity
2020, Pharmacological ResearchSTAT5a promotes the transcription of mature mmu-MIR-135a in 3T3-L1 cells by binding to both MIR-135a-1 and MIR-135a-2 promoter elements
2016, International Journal of Biochemistry and Cell BiologyCitation Excerpt :STAT5a, a notable member of the STAT family, modulates a series of important cellular activities by regulating the transcription of target genes involved in cell cycle regulation, cell differentiation and tumor apoptosis (Bromberg and Darnell, 2000; Darnell, 1997; O'Shea et al., 2013; O'Shea and Plenge, 2012; O'Shea et al., 2015; Vinkemeier, 2014). Several studies have shown that the expression levels of STAT genes increase during adipogenesis (Harp et al., 2001; Matthews et al., 2007; Shang and Waters, 2003), and the ectopic expression of STAT5a in NIH3T3 cells has been reported to induce adipogenesis (Floyd and Stephens, 2003). The present study proposed that C/EBPα, C/EBPβ, and PPARγ control adipogenesis by regulating STAT5a and STAT5b, with the former being necessary and the latter playing a supplementary role in adipogenesis (Jung et al., 2012).
Metformin enhances the anti-adipogenic effects of atorvastatin via modulation of STAT3 and TGF-β/Smad3 signaling
2015, Biochemical and Biophysical Research CommunicationsCitation Excerpt :A number of transcription factors, including peroxisome proliferator-activated receptor gamma (PPARγ) and the CCAATT enhancer binding protein (C/EBP) family, are required for adipogenic differentiation [3,4]. Recently, signal transducer and activator of transcription 3 (STAT3) was demonstrated to play a key role in adipogenesis through PPAR-dependent signaling [5,6], highlighting the importance of regulation of PPAR-STAT3 signaling in the context of high-fat-associated human diseases. Statins were primarily developed as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, and have been used clinically for the treatment of dyslipidemia [7].
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To whom correspondence should be addressed at Department of Nutrition, University of North Carolina at Chapel Hill, CB# 7400 McGavran-Greenberg Hall, Chapel Hill, NC 27599. Fax: (919) 966-7216. E-mail: [email protected].