Biochemical and Biophysical Research Communications
Volume 291, Issue 2, 22 February 2002, Pages 421-424
Regular ArticleActivation by Acidic pH of CLC-7 Expressed in Oocytes from Xenopus laevis
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A chloride channel in rat pancreatic acinar AR42J cells is sensitive to extracellular acidification and dependent on ROS
2020, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Marked external acidification (pH 4.5) induced a strong outwardly rectifying Cl− current, when transfected human ClC-4 clone to Chinese hamster ovary cells [25]. Similar strong outwardly rectifying Cl− currents induced by external acidification (pH 4.5) were observed in the ClC-7-cRNA-injected oocytes from Xenopus laevis [26]. Considering the properties of strong outward rectification and the marked low pH of the stimulus, the acid-induced currents ascribed to ClC-4 and ClC-7 might probably pertain to ASOR currents.
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