Original ArticleComparison of Different Iron Chelators as Protective Agents Against Acute Doxorubicin-induced Cardiotoxicity
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Decreasing doxorubicin-induced cardiotoxicity with Nigella sativa seed extract: Traditional medicine targeting a severe clinical problem
2022, Revista Portuguesa de CardiologiaMolecular Mechanisms of Anthracycline-Induced Cardiotoxicity
2017, Cardio-Oncology: Principles, Prevention and ManagementThe ameliorative effect of various antioxidants on Adriamycin-induced fetal renal abnormalities
2013, Journal of Pediatric UrologyCitation Excerpt :Administration of Deferoxamine, which is an iron-chelating agent and a superoxide anion scavenger, has been shown to ameliorate the cardiorenal toxicity of Adriamycin in rodents. Saad et al. have shown the preventive role of Deferoxamine against Adriamycin-induced renal toxicity in rats [27–29]. Major pathways leading to apoptosis can be inhibited by cytoprotective effects of zinc and vitamin E [30,31].
Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron
2009, Pharmacological ReportsCitation Excerpt :In contrast, DFO treatment of normal heart cells had no measurable cardioprotective effect against DOX toxicity, regardless of whether DFO was administered before or simultaneously with DOX [51]. Using a model of isolated mice atria acutely exposed to DOX, Voest et al. showed that DFO at a concentration of 200 μM was the most effective of the six chelators tested, including DXZ [148]. However, increasing the DFO concentration slightly to 500 μM caused its protective effects to disappear completely.
Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin
2005, Free Radical Biology and MedicineStudy of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits
2005, Pharmacological Research