Elsevier

Seminars in Immunology

Volume 12, Issue 4, August 2000, Pages 349-359
Seminars in Immunology

Regular Article
The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function

https://doi.org/10.1006/smim.2000.0218Get rights and content

Abstract

The CD45 phosphotyrosine phosphatase is one of the most abundant glycoproteins expressed on immune cells. Previously, the serpentine twists and turns of the CD45 research field have tended to draw attention to CD45 either as a positive or negative regulator of immune cell function. This review draws heavily on CD45 knockout mouse data to emphasize that CD45 has both positive and negative actions in regulating receptor thresholds, and these roles vary according to cell lineage and developmental stage. Previously conflicting results are reconciled in a model suggesting how CD45 regulates the p56lcktyrosine kinase in T cell signalling and development.

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    This review is dedicated to the memory of the late Matt Thomas.

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    Email: [email protected]

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