Regular ArticleComparativein VitroSkin Absorption and Metabolism of Coumarin (1,2-Benzopyrone) in Human, Rat, and Mouse☆
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A hypothetical skin sensitisation next generation risk assessment for coumarin in cosmetic products
2021, Regulatory Toxicology and PharmacologyCitation Excerpt :This was not wholly surprising as the evidence suggests that CYP2A6 has low expression levels in various skin models (Kazem et al., 2019; Wiegand et al., 2014). This is further corroborated by in vitro skin absorption and metabolism studies which show that coumarin is readily absorbed intact without undergoing cutaneous biotransformation (Beckley-Kartey et al., 1997). Further investigation to elucidate the mechanisms driving the skin sensitisation potency of coumarin, led us to coumarin 3,4-epoxide.
Transdermal toxicity of topically applied anticoagulant rodenticide warfarin in rats
2016, Environmental Toxicology and PharmacologyCoumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery
2014, Toxicology LettersCitation Excerpt :The highest skin accumulation and flux/PC were observed for osthole and coumarin, respectively. The great flux of coumarin was approved by previous research that topically applied coumarin from ethanol is rapidly and extensively absorbed into the circulation (Beckley-Kartey et al., 1997; Felter et al., 2006). Caution should be used in administering coumarin-containing products since coumarin uptake in the circulation can result in hepatotoxicity and lung injury (Abraham et al., 2010).
The contribution of dermal exposure to the internal exposure of bisphenol A in man
2011, Toxicology LettersPhysiologically based toxicokinetic modelling as a tool to assess target organ toxicity in route-to-route extrapolation-The case of coumarin
2011, Toxicology LettersCitation Excerpt :When the same dose is applied to the skin the peak concentration in blood varies. It depends on the rate of absorption characterised by the half-life of absorption and the extent of absorption which we varied both according to the experimental results of Beckley-Kartey et al. (1997), Ford et al. (2001), and Yourick and Bronaugh (1997): extent of absorption (60% and 100%, respectively) and rate of absorption (half-lives between 30 min and 960 min). With similar absorption half-lives (20 min for the oral and 30 min for the dermal absorption), identical doses (0.1 mg/kg) and extent of absorption (100%) the peak concentration after dermal exposure is considerably higher (51 μg/kg blood) as compared to oral exposure (3.1 mg/kg blood) (Fig. 2a and Table 3).
Local proinflammatory effects of repeated skin exposure to warfarin, an anticoagulant rodenticide in rats
2011, Biomedical and Environmental Sciences
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R. L. BronaughH. I. Maibach, Eds.
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