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Caveolins and Caveolae pp 157–179Cite as

Caveolins and Lung Function

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 729))

Abstract

The primary function of the mammalian lung is to facilitate diffusion of oxygen to venous blood and to ventilate carbon dioxide produced by catabolic reactions within cells. However, it is also responsible for a variety of other important functions, including host defense and production of vasoactive agents to regulate not only systemic blood pressure, but also water, electrolyte and acid-base balance. Caveolin-1 is highly expressed in the majority of cell types in the lung, including epithelial, endothelial, smooth muscle, connective tissue cells, and alveolar macrophages. Deletion of caveolin-1 in these cells results in major functional aberrations, suggesting that caveolin-1 may be crucial to lung homeostasis and development. Furthermore, generation of mutant mice that under-express caveolin-1 results in severe functional distortion with phenotypes covering practically the entire spectrum of known lung diseases, including pulmonary hypertension, fibrosis, increased endothelial permeability, and immune defects. In this Chapter, we outline the current state of knowledge regarding caveolin-1-dependent regulation of pulmonary cell functions and discuss recent research findings on the role of caveolin-1 in various pulmonary disease states, including obstructive and fibrotic pulmonary vascular and inflammatory diseases.

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Authors and Affiliations

  1. 2nd Department of Critical Care, National and Kapodistrian University of Athens Medical School, Athens, Greece

    Nikolaos A. Maniatis

  2. Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, USA

    Olga Chernaya, Vasily Shinin & Richard D. Minshall

  3. Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, USA

    Richard D. Minshall

  4. Center for Lung and Vascular Biology, University of Illinois at Chicago, Chicago, Illinois, USA

    Richard D. Minshall

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  1. Nikolaos A. Maniatis
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  2. Olga Chernaya
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  3. Vasily Shinin
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  4. Richard D. Minshall
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Correspondence to Richard D. Minshall .

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Editors and Affiliations

  1. Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Jean-François Jasmin PhD

  2. Departments of Cancer Biology, and Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Philippe G. Frank PhD  & Michael P. Lisanti MD, PhD  & 

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Maniatis, N.A., Chernaya, O., Shinin, V., Minshall, R.D. (2012). Caveolins and Lung Function. In: Jasmin, JF., Frank, P.G., Lisanti, M.P. (eds) Caveolins and Caveolae. Advances in Experimental Medicine and Biology, vol 729. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1222-9_11

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