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TRP channels: a TR(I)P through a world of multifunctional cation channels

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Abstract

The “transient receptor potential” (TRP) family of ion channels comprises more than 50 cation-permeable channels expressed from yeast to man. On the basis of structural homology, the TRP family can be subdivided in to seven main subfamilies: the TRPC (‘Canonical’) group, the TRPV (‘Vanilloid’) group, the TRPM (‘Melastatin’) group, the TRPP (‘Polycystin’), the TRPML (‘Mucolipin’), the TRPA (‘Ankyrin’) and the TRPN (‘NOMP’) family. The cloning and characterization of members of this cation channel family has exploded during recent years, leading to a plethora of data concerning TRPs in a variety of cell types, tissues and species. This paper briefly reviews the TRP superfamily and the basic properties of its many members as a reader’s guide in this Special Issue. Hopefully, a better understanding of TRP channel physiology will provide important insight into the relationship between TRP channel dysfunction and human diseases.

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Acknowledgements

We thank Dr. K. Talavera G. Uwsianik and F. Mahieu for helpful discussions. This work was supported by the Human Frontiers Science Programme (HFSP Research Grant Ref. RGP 32/2004), the Belgian Federal Government, the Flemish Government, the Onderzoeksraad KU Leuven (GOA 2004/07, F.W.O. G.0214.99, F.W.O. G. 0136.00; F.W.O. G.0172.03, Interuniversity Poles of Attraction Program, Prime Ministers Office IUAP).

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  1. Laboratorium voor Fysiologie, Department of Physiology, Campus Gasthuisberg, KU Leuven, Leuven, 3000, Belgium

    Bernd Nilius & Thomas Voets

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  1. Bernd Nilius
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Correspondence to Bernd Nilius.

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Nilius, B., Voets, T. TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Arch - Eur J Physiol 451, 1–10 (2005). https://doi.org/10.1007/s00424-005-1462-y

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