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KATP channelopathies in the pancreas

  • Integrative Physiology
  • Published:
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Abstract

Adenosine-triphosphate-sensitive potassium channels (KATP) are regulated by adenosine nucleotides, and, thereby, couple cellular metabolism with electrical activity in multiple tissues including the pancreatic β-cell. The critical involvement of KATP in insulin secretion is confirmed by the demonstration that inactivating and activating mutations in KATP underlie persistent hyperinsulinemia and neonatal diabetes mellitus, respectively, in both animal models and humans. In addition, a common variant in KATP represents a risk factor in the etiology of type 2 diabetes. This review focuses on the mechanistic basis by which KATP mutations underlie insulin secretory disorders and the implications of these findings for successful clinical intervention.

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Acknowledgments

The authors’ experimental work has been supported by National Institutes of Health Grant DK69445 (to Colin G. Nichols) and Washington University Diabetes Research and Training Center Pilot and Feasibility Award DK20579 (to J.C.K.).

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  1. Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA

    Maria S. Remedi & Joseph C. Koster

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Correspondence to Maria S. Remedi.

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Remedi, M.S., Koster, J.C. KATP channelopathies in the pancreas. Pflugers Arch - Eur J Physiol 460, 307–320 (2010). https://doi.org/10.1007/s00424-009-0756-x

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