Biochemical and Biophysical Research Communications
Cloning and characterization of gastrin receptor from ECL carcinoid tumor of ☆
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Cited by (122)
Stomach Hormones
2020, Hormonal Signaling in Biology and Medicine: Comprehensive Modern EndocrinologyHypergastrinemia Expands Gastric ECL Cells Through CCK2R<sup>+</sup> Progenitor Cells via ERK Activation
2020, Cellular and Molecular Gastroenterology and HepatologyCitation Excerpt :These results strongly suggest that hypergastrinemia does not induce cell division or proliferation in mature ECL cells, but on the contrary, new ECL cells appear to arise from stem/progenitor cells in the proliferating isthmus and neck region.29 In addition to expression of Hdc, ECL cells in the oxyntic mucosa are characterized by increased Cck2r expression.18 We previously reported that Cck2r expression marks antral stem cells, but detailed characterization of Cck2r-expressing cells in the corpus has not been performed.23
Stomach Hormones
2019, Hormonal Signaling in Biology and Medicine: Comprehensive Modern EndocrinologyThe role of cholecystokinin receptors in the short-term control of food intake
2013, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Each receptor has seven hydrophobic transmembrane domains with an extracellular NH2-terminus containing three to four N-linked glycosylation sites and an intracellular COOH-terminus, an E/DRY motif at the bottom of transmembrane domain III, and an NPXXY motif within transmembrane domain VII. There is little species variation in the cDNA sequence of CCK receptors.115–119 CCK binds to CCK1R and CCK2R with three different affinities: high, low, and very low.
Characterization of a novel five-transmembrane domain cholecystokinin-2 receptor splice variant identified in human tumors
2012, Molecular and Cellular EndocrinologyCitation Excerpt :The proliferative action of the CCK2R has been more abundantly documented on gastric, colonic and pancreatic cancer cell lines than on cells lines derived from tumors having high densities of CCK2R (Aly et al., 2004; Ferrand and Wang, 2006). However, several studies reported oncogenic role of the CCK2R in cancer cell lines originating from carcinoids (Kidd et al., xxxx; Nakata et al., 1992), small cell lung cancers (Sethi et al., 1993; Sethi and Rozengurt, 1992) and medullary thyroid carcinomas (Blaker et al., 2004, 2002). Interestingly, a precedent exists showing expression of a somatostatin receptor variant that may have important impact in clinical oncology.
Thermodynamic analysis does not allow discrimination of agonists and antagonists at human CCK<inf>2S</inf>-receptors
2008, European Journal of Pharmacology
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. D12817.