Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo
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2022, Journal of Thermal BiologyRecommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls
2021, Acta Pharmaceutica Sinica BGlutathione depletion, lipid peroxidation, and the antecedents of ferroptosis: What about cellular calcium ?
2019, Free Radical Biology and MedicineDetoxifying effect of pyridoxine on acetaminophen-induced hepatotoxicity via suppressing oxidative stress injury
2018, Food and Chemical ToxicologyCitation Excerpt :When detoxifying enzyme glutathione peroxidase (GPx) functions very inefficiently with rapid formation of free radicals, hepatocytes will be damaged due to oxidative stress (Dai and Cederbaum, 1995; Nakamura et al., 1974). Oxidative stress as measured by lipid peroxidation might be mechanistically important in APAP-induced hepatotoxicity (Hassoun et al., 2014; Noriega et al., 2000; Wendel et al., 1979). When NAPQI accumulates in the liverdue to GSH depletion, it can form adducts by covalently binding to hepatocellular proteins inside mitochondria, nucleus, and cytosolof hepatocytes and produce hepatotoxicity through hepatic necrosis (Kuralay et al., 1998; Yang et al., 2013).
Oxidative stress and acute hepatic injury
2018, Current Opinion in ToxicologyCitation Excerpt :An additional initiator of mitochondrial ROS generation could be lysosomal iron, which is released from disrupted lysosomes and taken up by mitochondria [19] through the calcium uniporter, generating hydroxyl radicals [20]. Though early studies had implicated lipid peroxidation in the process [21], this was later established to be due to the vitamin E-deficient diet the animals were subjected to, with very limited lipid peroxidation in animals on a normal diet [22]. In addition, there was no protection seen by vitamin E administration against APAP-induced liver injury in animals on a normal diet [22], ruling out a relevant role for lipid peroxidation in liver injury.
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