Importance of the lactonic ring in the activity of steroidal antialdosterones
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Spironolactone: 3-(-3-oxo-7α-acetylthio-17β-hydroxy-4-androsten-17 α-yl) proprionic acid γ-lactone; Canrenone: 3-(17β-hydroxy-6,7-dehydro-3-oxo-4-androsten-17αyl) proprionic acid γ-lactone; Dihydrocanrenone: 3 (17βhydroxy-6β, 7β dihydro-3-oxo-4-androsen-17-α-yl) proprionic acid γ-lactone; K-canrenoate: potassium 3-(17βhydroxy —6,7-dehydro-3-oxo-4-androsten-17α-yl) proprionate.
Copyright © 1980 Published by Elsevier Inc.