Research paperRegulation of nicotinic acetylcholine receptors on human neuroblastoma cells during differentiation
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Effects of galantamine on Β-amyloid release and beta-site cleaving enzyme 1 expression in differentiated human neuroblastoma SH-SY5Y cells
2010, Experimental GerontologyCitation Excerpt :Recent findings have demonstrated that Gal is also involved in APP processing (Lenzken et al., 2007). The purpose of the present study was to determine the effect of Gal on Aβ generation and BACE1 expression in the differentiated human neuroblastoma cell line (SH-SY5Y), which expresses choline acetyltransferase and both muscarinic and nicotinic receptors (Adem et al., 1987; Gould et al., 1992; Halvorsen et al., 1995). Our findings may suggest an additional mechanism of the pharmacological action of Gal on APP metabolism.
Nicotine stimulates transcriptional activity of the human dopamine transporter gene
2010, Neuroscience LettersNicotinic component of galantamine in the regulation of amyloid precursor protein processing
2007, Chemico-Biological InteractionsCitation Excerpt :We investigated the effect of GAL on the modulation of the non-amyloidogenic processing of APP. Differentiated neuroblastoma cells were chosen for our investigation because they are an ideal model for the study of the effect of AChE inhibitors on APP metabolism, since they express choline acetyltransferase and acetylcholinesterase activity and show muscarinic and nicotinic receptors [19–21]. The results indicate that GAL addition increased the amount of sAPPα released in the medium about three-fold over baseline.
Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor
2006, Brain ResearchCitation Excerpt :This could be due to the reduced density of nicotinic receptors on differentiated SH-SY5Y. As a matter of fact, it has been shown that treatment with retinoic acid, while increasing the number of TrkB receptors, decreased the number of nicotinic receptors by about 40% (Halvorsen et al., 1995) in this neuroblastoma cell line. There is also evidence that expression of the alpha-7 receptor tends to decrease with the passage number (Wonaccott, S., personal communication), although in our study, we did not use cells beyond passage 20.
Amino acid determinants of α7 nicotinic acetylcholine receptor surface expression
2000, Journal of Biological ChemistryCitation Excerpt :The small hump in the V201 peak was not observed in replicates of the experiment and is attributed to experimental variability. Although heterooligomeric non-neuronal forms of the nAChR exhibit assembly intermediates of monomer, dimer, trimer, and tetramer complexes (35, 36, 37), such assembly intermediates of α7 and α7–5HT3 chimeric receptors have not been shown to bind α-bungarotoxin (23, 47). In these studies, subunit protein of the M r (Fig. 7, arrowheads) that represents the toxin-binding species was not detected in gradient fractions on either side of the peak fractions, further supporting the notion that only oligomerized chimeric subunits bind α-bungarotoxin and that the toxin binding assay measures assembled receptors.